Troubled Worlds

Troubled sleep

Disrupted sleep is probably the most common complaint of parents with a new baby. Night waking increases in the second half of the first year of infant life and is more pronounced for breastfed infants. Sleep-related phenotypes of infants with Prader-Willi and Angelman syndromes suggest that imprinted genes of paternal origin promote greater wakefulness whereas imprinted genes of maternal origi...

Oil on troubled waters.

either by changing the ice sheet's basal thermal regime or by introducing water into the path of the ice stream through periodic drainage events. If this proves to be the case, it would substantially change our understanding of the effect of subglacial lakes on ice-sheet stability. It indicates that basal hydrology needs to be accounted for in numerical models of ice-sheet motion because it has...

A bridge over troubled waters.

Lung transplantation (LTx) remains the only therapeutic strategy for the treatment of end-stage respiratory failure in selected patients [1,2]. However, clinical scenario of LTx is rapidly changing. Two aspects still characterize LTx in comparison with the transplant of other solid organs. First, only a limited number of lung grafts is considered suitable for transplant within the donors’ pool....

The Autistic Neuron: Troubled Translation?

Autism is a complex genetic disorder, but single-gene disorders with a high prevalence of autism offer insight into its pathogenesis. Recent evidence suggests that some molecular defects in autism may interfere with the mechanisms of synaptic protein synthesis. We propose that aberrant synaptic protein synthesis may represent one possible pathway leading to autistic phenotypes, including cognit...

Aquaculture Navigates Through Troubled Waters